A Glycolysis-Fatty Acid Metabolic Axis Shapes Human Tfh Cell Function
Someshwar Nath Jha, Bhushan Nikam, Deepak Jena, Shilpa Sachan, Mamuni Swain, Poonam Coshic, Sunil K. Raghav, Nimesh Gupta
This study shows that early glycolysis inhibition enhances Tfh cell differentiation but impairs their function, revealing a glycolysis-fatty acid metabolic axis that controls Tfh function.
bioRxiv · Apr 3, 2026 · PreprintImmunology