Mechanism and Structure-Guided Optimization of SLC1A1/EAAT3-Selective Inhibitors in Kidney Cancer
Pooneh Koochaki, Biao Qiu, Jesse A. Coker, Alexander Earsley, Nancy S. Wang, Todd Romigh, Christopher M. Goins, Carleigh Salem, Dehui Mi, Emily Days, Joshua A. Bauer, Shaun R. Stauffer, Olga Boudker, Abhishek A. Chakraborty
This study determines the cryo-EM structure of SLC1A1 bound to an inhibitor, identifies its binding mechanism, and develops improved inhibitors with enhanced cytotoxicity in kidney cancer cells.
bioRxiv · Jul 3, 2025 · PreprintCancer Biology