CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions
Emmy Li, Camila Benitez, Steven C. Boggess, Mark Koontz, Indigo V.L. Rose, Delsy Martinez, Nina M. Dräger, Olivia M. Teter, Avi J. Samelson, Na’im Pierce, Erik M. Ullian, Martin Kampmann
The paper develops iAssembloids to study neuron-glia interactions using CRISPRi screens and finds GSK3β inhibits NRF2-mediated oxidative stress response and APOE-4 promotes neuronal activity.
Neuron · Jan 14, 2025Peer-reviewedNeuroscience