Author

Derek Chan

Salk Institute for Biological Studies

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 1 Neuroscience· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:clustering· 1

Frequent Co-Authors

Alaina Petrella· 2 shared Andrea Saldana Acerbo· 2 shared Anna BartlettiD· 2 shared Bing ReniD· 2 shared Carolyn O’ConnoriD· 2 shared Cesar BarraganiD· 2 shared Chumo CheniD· 2 shared Eshaan Soma· 2 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Alaina Petrella

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A Multimodal Single-Cell Epigenomic and 3D Genome Atlas of the Human Basal Ganglia

Wubin Ding, Amit Klein, Cindy Tatiana Báez-Becerra, Jonathan A. Rink, Anna Bartlett, Ruoxuan Wang, Qiurui Zeng, Rosa Castanon, Joseph R. Nery, Emma Osgood, William S. Owens, Alaina Petrella, Chumo Chen, Andrea Saldana Acerbo, Ariana S. Barcoma, , Joseph R. Ecker

This paper creates a multimodal single-cell atlas of the human basal ganglia, revealing epigenomic and 3D genome features across cell types and linking them to disease-associated genetic risk.

bioRxiv · Jun 23, 2026 · PreprintNeuroscience

Brain Region-Specific Epigenomic Reorganization and Altered Cell States in Alzheimer's Disease

Wenliang Wang, Peter Berube, Bing Yang, Rosa Castanon, Anna Bartlett, Kaushik Komandur, Joseph R. Nery, Cesar Barragan, Mia A. Kenworthy, Cynthia Valadon, Jordan Altshul, Alaina Petrella, Derek Chan, Chumo Chen, Andrea Saldana Acerbo, , Joseph R. Ecker

This study presents a single-cell multi-omic atlas of Alzheimer's disease brain regions, revealing region-specific epigenomic changes and altered cell states.

bioRxiv · Sep 29, 2025 · PreprintGenomics

Room Temperature Isothermal Colorimetric Padlock Probe Rolling Circle Amplification for Viral RNA Detection

Wilson Huang, Joyce Ting, Matthew Fang, Hannah Hsu, Jimmy Su, Tsuyoshi Misaki, Derek Chan, Justin Z. Yang, Ting-Yu Yeh, Kelly W. Yang, Vera Chien, Tiffany Huang, Andrew Chen, Claire Wei, Jonathan Hsu, Jude C. Clapper

This paper introduces a rapid, colorimetric, room-temperature viral RNA detection method using modified rolling circle amplification, showing high sensitivity and strain differentiation for SARS-CoV-2 and influenza viruses.

bioRxiv · Jun 12, 2020 · PreprintSynthetic Biology