Kilobase-scale compartments enabled by CRUSH reveal regulatory programs across cell types, single-cells, and ancient mammoths
Achyuth Kalluchi, Ben Nolan, Timothy E. Reznicek, Hannah L. Harris, Devika Udupa, Christopher T. Cummings, M. Jordan Rowley
The paper introduces CRUSH, a method to refine chromatin compartments to 1 kb resolution, revealing regulatory programs across cell types and a woolly mammoth's cold-adapted regulome.
bioRxiv · Apr 28, 2026 · PreprintGenomics