Fitness Landscape of the Fission Yeast Genome
Leanne Grech, Daniel Charlton Jeffares, Christoph Sadée, Maria Rodríguez‐López, Danny A. Bitton, Mimoza Hoti, Carolina Biagosch, Dimitra Aravani, Maarten Speekenbrink, Christopher J. R. Illingworth, Philipp H. Schiffer, Alison L. Pidoux, Pin Tong, Víctor A. Tallada, Robin C. Allshire, , Jürg Bähler
The paper uses transposon mutagenesis and a hidden Markov model to identify functional elements in the fission yeast genome, finding that 90% of the genome has fitness consequences.
Molecular Biology and Evolution · Apr 30, 2019Peer-reviewedGenomics