Reprogramming BCMA-Targeted CAR-T Cells through γ-Secretase Modulation Blocks Antigen Shedding and Extends CAR-T Longevity
Sheetal Sharma Sheetal, Varnit Chauhan, Zahoor Ahmad Bhat, Jyotirmoi Aich, Divya, Sunita Gupta, Divya Rashmi Singh, Raquib Alam, Drashti Dave, Preet Patel, Nisha Chaudhary, Deepak Kumar Singh, Vijay Pal Singh, Mohammad Husain, Amit Kumar Srivastava, , Tanveer Ahmad
This paper develops SHEDLOCK CAR-T cells that block BCMA shedding, enhancing their cytotoxicity and longevity in multiple myeloma models.
bioRxiv · Jan 23, 2026 · PreprintImmunology