Addition of Genetics to Quantitative MRI Facilitates Earlier Prediction of Dementia: A Non-invasive Alternative to Amyloid Measures
Natalie M. Schenker-Ahmed, Nafisa Bulsara, Lei Yang, Lei Huang, Arya Iranmehr, Jian Wu, Alexander M Graff, Tetiana Dadakova, Hyun-Kyung Chung, Dmitry Tkach, Ilan Shomorony, Naisha Shah, Peter Garst, Robyn Heister, Svetlana V. Bureeva, , Alzheimer’s Disease Neuroimaging Initiative
This paper develops a model combining polygenic risk scores and quantitative MRI to predict dementia onset up to eight years earlier than traditional methods.
bioRxiv · Aug 11, 2019 · PreprintBioinformatics