The ASNS inhibitor ASX-173 potentiates L-asparaginase anticancer activity
Victor Vyacheslavovich Tatarskiy, Wai-Kin Chan, Lin Tan, Alvina I. Khamidullina, Iqbal Mahmud, Shwetha V. Kumar, Julia Nuzhina, Sara A. Martinez, Bao Quoc Tran, Anna Skwarska, Nataliya G Pavlenko, Alena I. Dorofeeva, Marina Konopleva, Dmitry V. Genis, John N. Weinstein, , Philip L. Lorenzi
The paper identifies ASX-173 as a potent ASNS inhibitor that enhances the anti-cancer effects of L-asparaginase in leukemia and shows its potential across multiple cancer types.
bioRxiv · Jul 3, 2025 · PreprintCancer Biology