MIMOSA: Guiding De Novo Antibody Design with Natural Interaction Fingerprints
Brennan Abanades, Andrea Roncoli, Maniraj Bhagawati, Pan Kessel, Sabine Imhof-Jung, Dominique Doerr, Jonas Schilz, Stefania Vasilaki, Franziska Seeger, Alexandre M. J. J. Bonvin, Richard Bonneau, Vladimir Gligorijević, Anna Vangone
MIMOSA improves de novo antibody design by constraining generative models to known binder interfaces, achieving validated binders on targets where unconstrained methods fail.
bioRxiv · Sep 29, 2026 · PreprintBioinformatics