Molecular BiologybioRxivPreprint
Prime editing primarily induces undesired outcomes in mice
Tomomi Aida, Jonathan J. Wilde, Lixin Yang…·Guoping Feng
In mouse zygotes, prime editing installed 10 modifications across 6 genes, but undesired products such as large deletions outnumbered intended edits, traced to PE3 double-nicking.
43 citations