Multi-omics Characterization of Epigenetic and Genetic Risk of Alzheimer Disease in Autopsied Brains from two Ethnic Groups
Yiyi Ma, Dolly Reyes‐Dumeyer, Angel L. Piriz, Patricia Recio, Diones Rivera Mejía, Martin A. Medrano, Rafael Lantigua, Jean Paul Vonsattel, Giuseppe Tosto, Andrew F. Teich, Benjamin Ciener, Sandra Leskinen, Sharanya Sivakumar, Michael A. Deture, Duara Ranjan, , Badri Narayan Vardarajan
The paper identifies six genetic loci associated with Alzheimer's disease in Hispanics, showing both genetic and epigenetic risks, with some downstream effects on mRNA expression being ethnicity-specific.
medRxiv · Feb 12, 2024 · PreprintGenetic & Genomic Medicine