Massively parallel quantification of phenotypic heterogeneity in single cell drug responses
B. B. Yellen, J. S. Zawistowski, E. A. Czech, C. I. Sanford, E. D. SoRelle, M. A. Luftig, Z. G. Forbes, K. C. Wood, J. Hammerbacher
The paper develops a single-cell phenotyping tool to measure clonal properties at scale, applying it to study drug responses in AML clones and identifying rare resistance phenotypes.
bioRxiv · Dec 18, 2020Bioengineering