Pharmacologic Targeting of PDIA1 Inhibits NLRP3 Inflammasome Assembly and Activation
J. D. Rosarda, C. R. Stanton, E. B. Chen, M. J. Bollong, L. Wiseman
This study shows that AA147 inhibits NLRP3 inflammasome activity by covalently modifying PDIA1, suggesting PDIA1 as a therapeutic target for inflammatory diseases.
bioRxiv · Aug 21, 2023Cell Biology