Whole Body PBPK Model of Nasal Naloxone Administration to Measure Repeat Dosing Requirements During Fentanyl Overdose
A. Baird, S. A. White, R. Das, N. Tatum, E. Bisgaard
The paper develops a whole-body PBPK model to determine repeat naloxone dosing requirements during fentanyl overdose based on opiate amount and respiratory response.
bioRxiv · Apr 24, 2023 · PreprintPharmacology & Toxicology