Small-molecule antibiotic inhibitors of post-translational protein secretion
A. Economou, E. Burchacka, L. Angus, A. Marchand, M. B. Hamed, J. De Geyter, M. S. Loos, J. Anne, H. Klaassen, P. Chaltin, S. Karamanou
This study identifies small-molecule inhibitors of the bacterial Sec secretion pathway through a high-throughput screen, revealing compounds with antibacterial activity against multiple Gram-positive and Gram-negative species.
bioRxiv · Nov 17, 2020 · PreprintMicrobiology