Ubiquitin derived artificial binding proteins targeting oncofetal fibronectin reveal scaffold plasticity by beta strand slippage
A. Katzschmann, U. Haupts, A. Reimann, F. Settele, M. Gloser-Braunig, E. Fiedler, C. Parthier
The paper describes Affilin proteins that bind oncofetal fibronectin's EDB domain, revealing structural plasticity through beta-strand slippage in the ubiquitin scaffold.
bioRxiv · Jul 4, 2023Biochemistry