Mutated clones driving leukemic transformation are already detectable at the single cell level in CD34-positive cells in the chronic phase of primary myelofibrosis
S. Parenti, S. Rontauroli, C. Carretta, S. Mallia, E. Genovese, C. Chiereghin, C. Peano, L. Tavernari, E. Bianchi, S. Fantini, S. Sartini, O. Romano, S. Bicciato, E. Tagliafico, M. G. DELLA PORTA, R. MANFREDINI
The paper uses single cell genomics and transcriptomics to analyze CD34-positive cells in a PMF patient, identifying early mutations and clonal evolution associated with AML transformation.
bioRxiv · Dec 7, 2020Cancer Biology