Evolutionary instability of collateral susceptibility networks in ciprofloxacin resistant clinical Escherichia coli strains
V. Sorum, E. L. Oynes, A. S. Moller, K. Harms, O. Samuelsen, N. L. Podnecky, P. J. Johnsen
This study shows that collateral networks in ciprofloxacin-resistant E. coli strains are evolutionarily unstable due to compensatory mutations, particularly affecting rpoS.
bioRxiv · Oct 26, 2021Microbiology