ImmunologybioRxiv
The Beta secretase BACE1 drives fibroblasts activation in Systemic Sclerosis through the APP/Beta-catenin/Notch signalling axis
C. W. Wasson, E. De Lorenzis, E. M. Clavane…·P. J. Meakin
This study shows BACE1 drives fibroblast activation in systemic sclerosis via the APP/Beta-catenin/Notch axis and identifies BACE1 as a potential therapeutic target.
DOI 10.1016/j.jid.2024.03.024