How the initiating ribosome copes with (p)ppGpp to translate mRNAs
D. S. Vinogradova, P. Kasatsky, E. Maksimova, V. Zegarra, A. Paleskava, A. L. Konevega, P. Milon
The paper investigates how the initiation factor IF2 senses the ppGpp to GTP ratio to regulate translation initiation in bacteria, showing that mRNA demand influences the competition between ppGpp and GTP for IF2 binding.
bioRxiv · Feb 10, 2019Biochemistry