Overcoming PARP inhibitor resistance by inducing a homologous recombination repair defective phenotype with ATR, CHK1 and WEE1 inhibitors
H. L. Smith, E. Willmore, L. Prendergast, N. J. Curtin
This paper shows that ATR, CHK1, and WEE1 inhibitors induce an HRD phenotype, making cells sensitive to PARP inhibitors.
bioRxiv · Jul 5, 2023 · PreprintCancer Biology