Preclinical systematic review of CCR5 antagonists as cerebroprotective and stroke recovery enhancing agents
Ayni Sharif, Matthew Strider Jeffers, Dean A. Fergusson, Raj Bapuji, Stuart Gordon Nicholls, John Humphrey, Warren Johnston, Ed Mitchell, Mary-Ann Speirs, Laura Stronghill, Michele Vuckovic, Susan Wulf, Risa Shorr, Dar D Dowlatshahi, Dale Corbett, Manoj Mathew Lalu
This study reviews preclinical evidence on CCR5 antagonists' effects on stroke outcomes and recovery, finding reduced infarct volume and improved behavioral outcomes, but highlighting significant bias and knowledge gaps.
eLife · Apr 7, 2025Peer-reviewedNeuroscience