One-carbon metabolism sustains effector T cell function through cell-surface glycosylation
Peng Wang, Amy Yu, Mohammed Mutaher, Almut S. Eisele, Sarah Mouche, Kaitlyn Hung, Reece Larson, Madeline Gish, Margaret D. Zimmer, Jeannette R. Brook, Miriam McNerney, Lea Hammer, Arjun Garg, Efrat Ozeri, Alan Y. L. Wong, , Naama Kanarek
This study shows folate deprivation impairs CD8+ T cell function by disrupting cell surface glycosylation, and increasing folate uptake enhances T cell anti-tumor activity.
bioRxiv · Oct 7, 2026 · PreprintCell Biology