Txn-Txnrd1 system supports redox rewiring during polyaneuploid transition and protects giant cancer cells at new redox homeostasis
Kinga Kołacz-Milewska, Karolina Gronkowska, Sylwia Michlewska, Markus Absenger, Eleonore Froehlich, Agnieszka Robaszkiewicz
The paper identifies the Txn-Txnrd1 system as critical for redox homeostasis in polyaneuploid giant cancer cells, linking it to therapy resistance and poor patient outcomes.
bioRxiv · Aug 31, 2026 · PreprintCancer Biology