An Integrated Experimental and Informatics Strategy Enables Large Proteoform Identification in Top-Down Proteomics
Matthew S Fischer, Eli J Larson, Ryan K Schroeder, Hsin-Ju Chan, Heewon Choi, Thomas S Weir, Andrew J Perciaccante, Carmen C Sucharov, Yang Lu, Ying Ge
The paper presents an integrated experimental and informatics strategy to improve identification of large proteoforms in top-down proteomics, achieving identification of proteoforms up to 223 kDa.
bioRxiv · Nov 2, 2026 · PreprintBiochemistry