TwinCell: Large Causal Cell Model for Reliable and Interpretable Therapeutic Target Prioritisation
Jean-Baptiste Morlot, Thomaz Lüscher Dias, Sébastien Légaré, Alessandro Romualdi, Elie Hatem, Yann Abraham
TwinCell identifies therapeutic targets by analyzing cell state transitions using a causal model trained on in vitro data, outperforming existing methods in both virtual and clinical settings.
bioRxiv · Mar 6, 2026 · PreprintSystems Biology