Top-down, knowledge-based genetic reduction of yeast central carbon metabolism
Eline D. Postma, Lucas G. F. Couwenberg, Roderick N. van Roosmalen, Jordi Geelhoed, Philip A. de Groot, Pascale A. S. Daran-Lapujade
The paper reduces genetic complexity in yeast central carbon metabolism by deleting 35 genes, resulting in minimal phenotypic changes under various conditions.
mBio · Sep 21, 2022Peer-reviewedGenetics