Cell BiologybioRxivPreprint
TNFα-driven Aβ aggregation, synaptic dysfunction and hypermetabolism in human iPSC-derived cortical neurons
Alicia González Díaz, Elisa Belli, Benedetta Mannini…·Michele Vendruscolo
This study develops a human iPSC-derived cortical neuron model that recapitulates AD pathology through TNFα treatment, showing Aβ aggregation, synaptic dysfunction, and hypermetabolism.
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