A Non-Viral CRISPR/Cas9 HDR Platform for Stable Engineering of Solid Tumor Models.
Shoaib Afzal, Maximilian Pilgram, Julia Macos, Emily Ohlendorf, Lena Olivia Raab, Jonas Kath, Viktor Glaser, Ana-Maria Nitulescu, Casper F. T. van der Ven, Chahrazad Lachiheb, Maria Stecklum, Norman Michael Drzeniek, Kathleen Anders, Dimitrios L. Wagner, Ralf Kuehn, , Michael Launspach
This paper develops a non-viral CRISPR/Cas9 HDR platform for stable transgene knock-in in solid tumor models, achieving up to 60% efficiency in neuroblastoma cells.
bioRxiv · Jun 4, 2026 · PreprintBioengineering