Chemical augmentation of the validated HepaRGTM CYP induction test method Part 2: Additional laboratory study supported by mRNA analysis
Emma Quartermain, Jinkang Zhang, Tim H. Marczylo, Timothy W. Gant, Miriam Naomi Jacobs
A third laboratory transferred the HepaRG CYP induction assay to six augmentation and four additional non-pharmaceutical chemicals; parallel mRNA data supported enzyme activity calls, with CYP3A4 most concordant.
bioRxiv · Jun 20, 2026 · PreprintPharmacology & Toxicology✦ In-depth digest