Selective Nerve Block of A- or C-Afferents Confirms Dual Role in Touch Pleasantness but Not Touch-Pain Modulation
Benedetta Albinni, Lindsey Crankshaw, Emrys Jones, Vincent J. Alasha, Marisa S. Zimmerman, Nathaniel M. Schuster, Engy T. Said, Irina A. Strigo, Laura K. Case
This study uses nerve blocks to show that both A- and C-fibers contribute to touch pleasantness, but only C-fibers modulate pain.
bioRxiv · Oct 14, 2026 · PreprintNeuroscience