Methylation Clocks Do Not Predict Age or Alzheimer's Disease Risk Across Genetically Admixed Individuals
Sebastián Cruz-González, Ogechukwu Okpala, Esther Gu, Lissette Gomez, Makaela Mews, Jeffery M. Vance, Michael L. Cuccaro, Mario Cornejo‐Olivas, Briseida E. Feliciano‐Astacio, Goldie S. Byrd, Jonathan L. Haines, Margaret Ann Pericak‐Vance, Anthony J. Griswold, William S. Bush, John A. Capra
The paper evaluates methylation clocks in genetically diverse populations and finds they are less accurate in admixed cohorts and fail to consistently predict age acceleration in Alzheimer's disease cases.
bioRxiv · Oct 16, 2024 · PreprintGenomics