Patient-derived IgG Amplifies Fcγ Receptor-Dependent Colonic Inflammation During Immune Checkpoint Blockade
Iryna Voloshyna, Y. Patskovsky, Sabina Sandigursky, Chaitra Sreenivasaiah, Erol C Bayrakta, Ethan Tardio, Andrea V. Lopez, Stanzin Idga, Courtney Ng, Milad Ibrahim, Clara Goldberg, Anastasia Zhurova, Ryah Freih, Justin Mastroianni, Yuan Hao, , Michelle Krogsgaard
The paper shows that patient-derived IgG from those with severe immune-related colitis amplifies inflammation during immune checkpoint blockade in humanized FcγR mice.
bioRxiv · Sep 11, 2026 · PreprintCancer Biology