Synaptic microRNA dysregulation orchestrates aberrant glutamatergic transmission in a human neuronal model of 22q11.2 deletion syndrome
Weibo Niu, Jidong Guo, Ximing Ran, David Parker, Xiangru Li, Shaojun Yu, Sidney Imes, Ryan H. Purcell, Christina Michalski, Eric Guo, Sophia Y Jiang, Ethan Xu, Gary Jonathan Bassell, Jennifer Gladys Mulle, Opal Ousley, , Zhexing Wen
This study identifies dysregulated synaptic microRNAs in 22q11DS neurons that drive aberrant glutamatergic transmission and synaptic plasticity, linking genetic deletion to psychosis risk.
bioRxiv · Oct 15, 2026 · PreprintNeuroscience