A combination of EWSR1-FLI1 with loss of one EWSR1 allele promotes damage in the mitotic spindle and sensitization to microtubule-destabilizing agent
The paper shows that combining EWSR1-FLI1 expression with EWSR1 knockdown increases mitotic spindle damage and sensitivity to microtubule-destabilizing agents in Ewing sarcoma cells.
bioRxiv · Jun 19, 2026 · PreprintCancer Biology