Sequential acquisition of 1p31.1-p12 LOH and 1q Gain is a common double-hit event in relapsed/refractory myeloma
Naser Ansari‐Pour, Sarah Gooding, Mohammad H. Kazeroun, Seyed Alireza Hasheminasab, Evie Fitzsimons, Selina J Chavda, Alessandro Laganà, Erin Flynt, Udo C. T. Oppermann, Karthik Ramasamy, Kwee Yong, Angela Hamblin, Jill Corre, Hervé Avet‐Loiseau, Nikhil C. Munshi, , Anjan Thakurta
The paper identifies a therapy-driven genomic double-hit (1pCEN LOH and 1q gain) in relapsed/refractory myeloma, associated with poor prognosis and clonal expansion.
bioRxiv · May 21, 2026 · PreprintCancer Biology