F. Broccatelli

Estimating Organ-to-Plasma Ratios in physiologically based PK modeling: a simplified approach for early drug discovery

This paper proposes a simplified method to estimate organ-to-plasma ratios in PBPK modeling using volume of distribution data, showing improved accuracy compared to in vitro-based approaches.

Application of mechanistic multiparameter optimization and large scale in vitro to in vivo pharmacokinetics correlations to small molecule therapeutic projects

This paper applies mechanistic multiparameter optimization to drug discovery, showing it can prioritize compounds effectively for clinical trials with high accuracy.