Single cell fitness landscapes induced by genetic and pharmacologic perturbations in cancer
S. Salehi, F. Kabeer, N. Ceglia, M. Andronescu, M. Williams, K. R. Campbell, T. Masud, B. Wang, J. Biele, J. Brimhall, J. Ting, A. W. Zhang, C. H. OFlanagan, F. Dorri, N. Rusk, , S. P. Shah
This study develops a quantitative fitness model to analyze clonal dynamics in cancer under genetic and pharmacologic perturbations, revealing how mutations and drug resistance shape tumor evolution.
bioRxiv · May 8, 2020Cancer Biology