Author

F. Hooft

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Cancer Biology· 1

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Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1

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D. W. H. Swenson· 1 shared J. Vreede· 1 shared P. G. Bolhuis· 1 shared S. Roet· 1 shared

Activity by Year

2020-2020 · peak 1/yr

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4 top collaborators · 6 mutual co-author links

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1 shared paperCancer Biology

D. W. H. Swenson

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1 paper

Recent·Most cited

Path sampling simulations reveal how the Q61L mutation restricts the dynamics of KRas

S. Roet, F. Hooft, P. G. Bolhuis, D. W. H. Swenson, J. Vreede

The paper uses path sampling simulations to show that the Q61L mutation in KRas restricts its dynamic transitions, favoring rigid states over flexible ones, which may inform therapeutic strategies.

bioRxiv · Feb 28, 2020 · PreprintCancer Biology