A single domain intrabody targeting the follicle-stimulating hormone receptor (FSHR) impacts FSH-induced G protein-dependent signalling
P. Raynaud, V. Jugnarain, O. Vaugrente, A. Vallet, T. Boulo, C. Gauthier, A. Inoue, N. Sibille, C. Gauthier, F. Jean-Alphonse, E. Reiter, P. Crepieux, G. Bruneau
The paper characterizes an intrabody that modulates FSHR signaling by reducing cAMP production without affecting Gs recruitment.
bioRxiv · Aug 7, 2023Pharmacology & Toxicology