The natural stilbenoid (-)-hopeaphenol inhibits cellular entry of SARS-CoV-2 USA-WA1/2020, B.1.1.7 and B.1.351 variants
I. Tietjen, J. Cassel, E. T. Register, X. Y. Zhou, T. E. Messick, F. Keeney, L. D. Lu, K. D. Beattie, T. Rali, H. C. Ertl, J. M. Salvino, R. A. Davis, L. J. Montaner
This paper identifies (-)-hopeaphenol and related stilbenoids as potent inhibitors of SARS-CoV-2 entry across multiple variants by blocking spike protein-ACE2 interaction.
bioRxiv · Apr 29, 2021Microbiology