Anthracyclins increase free PUFAs and etherPEs with PUFAs as potential hallmarks of lipid peroxidation and ferroptosis
D. Balgoma, F. Kullenberg, C. Calitz, M. Kopsida, F. Heindryckx, H. Lennernas, M. Hedeland
The paper investigates how anthracyclins affect lipid metabolism in liver cancer cells, finding increased PUFAs and etherPEs with PUFAs, suggesting their potential as markers for ferroptosis and as adjuvants for anthracyclin therapy.
bioRxiv · Feb 16, 2021 · PreprintCancer Biology