Quaternary structural convergence and structural diversification of prion assemblies at the early replication stage
A. Igel-Egalon, F. Lafferriere, M. Moudjou, M. Merzach, T. Knapple, L. Herzog, F. Reine, M. Doumic, H. Rezaei, V. Beringue
This study investigates the structural convergence and diversification of PrPSc assemblies during prion replication, revealing a secondary templating pathway that explains structural diversification.
bioRxiv · Mar 20, 2019 · PreprintBiochemistry