Upregulation of MAM by C99 disrupts ACSL4 activity and phospholipid homeostasis in Alzheimer disease.
Jorge Montesinos, Taekyung Yun, Ivan Daniel Salomon-Cruz, Sara Camila Agudelo-Castrillon, M. Uceda, A.C. Ferre, Cristina Anton-Barros, Nardhy Gomez‐Lopez, Rishi R. Agrawal, Delfina Larrea, KEVIN R. VELASCO, Anna Fernàndez‐Bernal, E. Benitez, Xiongwei Zhu, Eric A. Schon, , Estela Área-Gómez
This study identifies how C99 disrupts ACSL4 activity and phospholipid homeostasis in Alzheimer's disease by remodeling MAMs and altering PC composition.
bioRxiv · Nov 25, 2025 · PreprintMolecular Biology