SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells
C. Martinat, A. Cormier, J. Tobaly-Tapiero, N. Palmic, N. Casartelli, S. A. Coggins, J. Buchrieser, M. Persaud, F. Diaz-Griffero, L. Espert, G. Bossis, P. Lesage, O. Schwartz, B. Kim, F. Margottin, , A. Zamborlini
This study shows that SUMOylation of SAMHD1 at K595 is necessary for its antiviral activity in non-cycling cells, independent of its dNTPase function.
bioRxiv · Jun 4, 2020Microbiology