Hijacking SARS-Cov-2/ACE2 receptor interaction by natural and semi-synthetic steroidal agents acting on functional pockets on receptor binding region
A. Carino, F. Moraca, B. Fiorillo, S. Marcano, V. Sepe, M. Biagioli, C. Finamore, S. Bozza, D. Francisci, E. Distrutti, B. Catalanotti, A. Zampella, S. Fiorucci
This study identifies steroidal agents that inhibit SARS-CoV-2 entry by targeting binding pockets on the Spike protein's receptor-binding domain.
bioRxiv · Jun 10, 2020Pharmacology & Toxicology