Molecular determinants of TRAF6 binding specificity suggest that native interaction partners are not optimized for affinity
J. C. Halpin, D. Whitney, F. Rigoldi, V. Sivaraman, A. Singer, A. E. Keating
The paper identifies TRAF6 MATH domain binding preferences using combinatorial peptide libraries and structural modeling, revealing that native ligands are not optimized for affinity.
bioRxiv · May 8, 2022Biochemistry