Integrated single cell and bulk multi-omics reveals heterogeneity and early changes in pathways associated with cetuximab resistance in HNSCC sensitive cell lines
L. T. Kagohara, F. Zamuner, M. Considine, J. Allen, S. Yegnasubramanian, D. A. Gaykalova, E. J. Fertig
The paper uses single cell and bulk multi-omics to study early resistance mechanisms in HNSCC cells treated with cetuximab, identifying TFAP2A and EMT as independent pathways.
bioRxiv · Nov 6, 2019Cancer Biology