INPP5E regulates CD3ζ enrichment at the immune synapse by phosphoinositide distribution control
T.-Y. Chiu, F.-H. Yang, W. M. Chong, H.-C. Tsai, W.-J. Wang, J.-C. Liao
This study shows INPP5E regulates CD3ζ localization at the immune synapse by controlling phosphoinositide distribution, affecting TCR signaling and IL-2 secretion.
bioRxiv · Jan 6, 2021Cell Biology